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- Title
Acneiform rash as a side effect of selumetinib in a child with neurofibromatosis type 1 treated for inoperable plexiform neurofibromas: Good results with doxycycline.
- Authors
Volontè, Martina; Isoletta, Eugenio; Gordon, Shaul; Foiadelli, Thomas; Bassanese, Francesco; Rossi, Alessandra; Marseglia, Gian Luigi; Savasta, Salvatore; Brazzelli, Valeria
- Abstract
Systemic therapy with doxycycline (200 mg/day for 15 days) was then successfully administrated and the patient reached complete persistent clinical remission without scarring (Figure 1C,D). Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. Neurofibromatosis type 1 (NF1) is an autosomal dominant multiorgan syndrome with an estimated global prevalence of 1/4000 involving aberrations of the I NF1 i gene on chromosome 17.
- Subjects
NEUROFIBROMA; ACNEIFORM eruptions; NEUROFIBROMATOSIS 1; DOXYCYCLINE; TUMOR suppressor genes; TUMOR suppressor proteins; PERIPHERAL nerve tumors
- Publication
Dermatologic Therapy, 2022, Vol 35, Issue 8, p1
- ISSN
1396-0296
- Publication type
Article
- DOI
10.1111/dth.15607