We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Differential effects of motilin on interdigestive motility of the human gastric antrum, pylorus, small intestine and gallbladder.
- Authors
Luiking, Y. C.; Akkermans, L. M. A.; Van Der Reijden, A. C.; Peeters, T. L.; Van Berge Henegouwen, G. P.
- Abstract
Motilin was infused in this study with the aim of examining refractory characteristics for motilin stimulation of antral phase III and fasting gallbladder emptying. Moreover, interdigestive pyloric and small intestinal motility from duodenum to ileum were studied, as these may be target organs for motilin. Eight fasting, healthy male volunteers received, on separate subsequent days, repeated infusions of [sup13]leucine-motilin (8 pmol (kg min)[sup-1] for 5 min) or saline at 30 rain after phase IIIs in the duodenum. Interdigestive motility of the antrum, pylorus, duodenum, jejunum and ileum was measured for maximum 10 h by using a 21-lumen perfused catheter. Gallbladder motility was measured by ultrasonography. Motilin infusions induced antral phase IIIs, but only after a preceding phase Ill of duodenal origin. Under this condition, time-interval to phase III at the duodenal recording site was 30 ± 13 (SEM) rain after motilin, compared with 79 ± 14 rain after saline (P < 0.01), and compared with 121 ± 13 rain for motilin infusion following an antral phase HI (P < 0.001). Motilin did not affect small intestinal motility or isolated pyloric pressure waves (IPPWs). However, the number of IPPWs was significantly affected by the origin of the preceding phase III, irrespective of whether motilin or saline was infused. Gallbladder volume decreased significantly within 10 rain after each motilin infusion. We conclude that this study clearly demonstrates differential regional effects of motilin. Motilin initiates antral phase Ills, but stimulation is subject to a refractory period which is clearly prolonged after a preceding antral phase III. Motilin induced gallbladder emptying, however, is not subject to a refractory state...
- Subjects
MOTILIN; GASTROINTESTINAL system; INTESTINES; GALLBLADDER
- Publication
Neurogastroenterology & Motility, 2003, Vol 15, Issue 2, p103
- ISSN
1350-1925
- Publication type
Article
- DOI
10.1046/j.1365-2982.2003.00395.x