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- Title
Comment on: "Fibroblast growth factor 21 controls mitophagy and muscle mass" by Oost et al.
- Authors
Wu, Yeshun; Zhu, Bin; Chen, Zijun; Duan, Jiahao; Yang, Ling
- Abstract
We have read with great interest the article by Oost I et al i ., in which the authors demonstrated that fibroblast growth factor 21 (FGF21) induces muscle atrophy and weakness via up-regulation of mitophagy protein Bnip3.[1] Although the study design and conclusions are reasonable, we have the following concerns that need to be addressed. We totally agree with the conclusion that FGF21 could induce muscle atrophy and weakness,[1] while the role of classical FGF21 signalling pathway in muscle atrophy and weakness cannot be ignored. Thus, we speculate that extremely elevated FGF21 level may cause a relative deficiency in the levels of -Klotho, which would weaken the anti-aging effect, thus leading to muscle mass loss; in other words, muscle atrophy may be attributed to the imbalance in FGF21- -Klotho signalling caused by relative up-regulation of FGF21.
- Subjects
FIBROBLAST growth factors; MUSCLE mass; SOMATOMEDIN; BODY composition; MUSCLE weakness
- Publication
Journal of Cachexia, Sarcopenia & Muscle, 2020, Vol 11, Issue 1, p336
- ISSN
2190-5991
- Publication type
Article
- DOI
10.1002/jcsm.12465