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- Title
Non-mucinous lepidic predominant adenocarcinoma presenting with extensive aerogenous spread.
- Authors
Yusuke Takanashi; Shogo Tajima; Masaru Tsukui; Kazuya Shinmura; Takamitsu Hayakawa; Tsuyoshi Takahashi; Hiroshi Neyatani; Kazuhito Funai
- Abstract
An extremely rare case of non-mucinous lepidic-predominant invasive adenocarcinoma (LPA) showing extensive aerogenous spread with a pneumonic presentation is reported. A 73-year-old woman was referred to our hospital because of an infiltrative shadow on chest x-ray. Chest computed tomography revealed extensive ground glass opacities in the right lower lobe, which was accompanied by infiltrative shadow with a pneumonic presentation. Invasive mucinous adenocarcinoma was presumed, and a partial resection of the right lower lobe was done. Histopathological examination revealed lepidic growth-predominant invasive adenocarcinoma with Clara type tumor cells, and there were innumerable aerogenous metastases also consisting of Clara cells. Because Alcian Blue and periodic acid-Schiff staining disclosed no mucus, the tumor was diagnosed as a non-mucinous LPA. The patient showed a poor response to 5 courses of pemetrexed, and she died one year after the diagnosis due to cancer progression. Nonmucinous LPA showed a rare presentation characterized by extensive aerogenous spread followed by a poor prognosis.
- Subjects
ADENOCARCINOMA; COMPUTED tomography; CANCER invasiveness; MUCINOUS adenocarcinoma; CANCER cells
- Publication
Rare Tumors, 2016, Vol 8, Issue 4, p169
- ISSN
2036-3605
- Publication type
Article
- DOI
10.4081/rt.2016.6580