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- Title
Concentration of cisplatin-incorporated polymeric micelles in a murine solid tumor evaluated using PIXE analysis.
- Authors
Terakawa, A.; Ishii, K.; Matsuyama, S.; Kikuchi, Y.; Kawamura, T.; Takahashi, Y.; Miura, Y.; Karahashi, M.; Kusano, K.; Yamazaki, H.; Funaki, Y.; Mizuno, K.; Ito, N.; Wada, S.; Sera, K.
- Abstract
We report an elemental analysis of murine solid tumors treated with cisplatin-incorporated polymeric micelles (NC-6004) to evaluate the concentration of the drug in the tumor tissue using conventional particle-induced X-ray emission (PIXE) analysis, as well as the spatial distribution in the tumor section using sub-millimeter PIXE analysis. The results reveal that the platinum concentration in the tumor treated with NC-6004 was higher than in that treated with cisplatin, whereas no significant difference was found in platinum concentration between NC-6004 and cisplatin samples in the normal tissue. This suggests that NC-6004 can both provide therapeutic efficacy and reduce the side effects caused by conventional treatment using cisplatin. These results show that PIXE analysis is a powerful tool for research into drug delivery systems.
- Subjects
CISPLATIN; DRUG delivery systems; TUMORS; MICELLES; PARTICLE induced X-ray emission
- Publication
International Journal of PIXE, 2014, Vol 24, Issue 1/2, p41
- ISSN
0129-0835
- Publication type
Article
- DOI
10.1142/S0129083514500053