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Upregulation of Phosphodiesterase 7A Contributes to Concurrent Pain and Depression via Inhibition of cAMP-PKA-CREB-BDNF Signaling and Neuroinflammation in the Hippocampus of Mice.
- Published in:
- International Journal of Neuropsychopharmacology, 2024, v. 27, n. 10, p. 1, doi. 10.1093/ijnp/pyae040
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- Publication type:
- Article
Cyclic Nucleotide Phosphodiesterases in Alcohol Use Disorders: Involving Gut Microbiota.
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- International Journal of Neuropsychopharmacology, 2023, v. 26, n. 1, p. 70, doi. 10.1093/ijnp/pyac060
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- Publication type:
- Article
The Phosphodiesterase-4 Inhibitor Roflumilast, a Potential Treatment for the Comorbidity of Memory Loss and Depression in Alzheimer's Disease: A Preclinical Study in APP/PS1 Transgenic Mice.
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- International Journal of Neuropsychopharmacology, 2020, v. 23, n. 10, p. 700, doi. 10.1093/ijnp/pyaa048
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- Publication type:
- Article
The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice.
- Published in:
- International Journal of Neuropsychopharmacology, 2013, v. 16, n. 5, p. 1033, doi. 10.1017/S1461145712000831
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- Publication type:
- Article
The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats.
- Published in:
- International Journal of Neuropsychopharmacology, 2012, v. 15, n. 6, p. 749, doi. 10.1017/S1461145711000836
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- Publication type:
- Article
Ischemic stroke/transient ischemic attack in adults with primary immune thrombocytopenia: a meta-analysis.
- Published in:
- 2021
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- Publication type:
- journal article
Transcriptome analysis of fasudil treatment in the APPswe/PSEN1dE9 transgenic (APP/PS1) mice model of Alzheimer's disease.
- Published in:
- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-10554-9
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- Publication type:
- Article
Inhibition of Rho Kinase by Fasudil Ameliorates Cognition Impairment in APP/PS1 Transgenic Mice via Modulation of Gut Microbiota and Metabolites.
- Published in:
- Frontiers in Aging Neuroscience, 2021, v. 13, p. 1, doi. 10.3389/fnagi.2021.755164
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- Publication type:
- Article
Neuroprotective Effects of Molecular Hydrogen: A Critical Review.
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- Neuroscience Bulletin, 2021, v. 37, n. 3, p. 389, doi. 10.1007/s12264-020-00597-1
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- Publication type:
- Article
Suberitolactams A−D and Suberitopyridines A−B: New γ‐lactam and Pyridine Alkaloids Isolated from the South China Sea Sponge Pseudospongosorites suberitoides.
- Published in:
- Chemistry & Biodiversity, 2024, v. 21, n. 8, p. 1, doi. 10.1002/cbdv.202400939
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- Publication type:
- Article
β‐Glucan attenuates cognitive impairment of APP/PS1 mice via regulating intestinal flora and its metabolites.
- Published in:
- CNS Neuroscience & Therapeutics, 2023, v. 29, n. 6, p. 1690, doi. 10.1111/cns.14132
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- Publication type:
- Article
Inhibition of phosphodiesterase‐4 in the spinal dorsal horn ameliorates neuropathic pain via cAMP‐cytokine‐Cx43 signaling in mice.
- Published in:
- CNS Neuroscience & Therapeutics, 2022, v. 28, n. 5, p. 749, doi. 10.1111/cns.13807
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- Publication type:
- Article
A novel PDE9 inhibitor WYQ‐C36D ameliorates corticosterone‐induced neurotoxicity and depression‐like behaviors by cGMP‐CREB‐related signaling.
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- CNS Neuroscience & Therapeutics, 2018, v. 24, n. 10, p. 889, doi. 10.1111/cns.12864
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- Publication type:
- Article
The neuroprotective and antidepressant‐like effects of Hcyb1, a novel selective PDE2 inhibitor.
- Published in:
- CNS Neuroscience & Therapeutics, 2018, v. 24, n. 7, p. 652, doi. 10.1111/cns.12863
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- Publication type:
- Article
Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System.
- Published in:
- Scientific Reports, 2017, p. 40115, doi. 10.1038/srep40115
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- Publication type:
- Article
Biochanin A Attenuates Ovariectomy-Induced Cognition Deficit via Antioxidant Effects in Female Rats.
- Published in:
- Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2021.603316
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- Publication type:
- Article
Adjuvant therapy with Astragalus membranaceus for post-stroke fatigue: a systematic review.
- Published in:
- Metabolic Brain Disease, 2020, v. 35, n. 1, p. 83, doi. 10.1007/s11011-019-00483-4
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- Publication type:
- Article
The Rho kinase inhibitor fasudil attenuates Aβ<sub>1–42</sub>-induced apoptosis via the ASK1/JNK signal pathway in primary cultures of hippocampal neurons.
- Published in:
- Metabolic Brain Disease, 2019, v. 34, n. 6, p. 1787, doi. 10.1007/s11011-019-00487-0
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- Publication type:
- Article
Therapeutic potentials of the Rho kinase inhibitor Fasudil in experimental autoimmune encephalomyelitis and the related mechanisms.
- Published in:
- Metabolic Brain Disease, 2019, v. 34, n. 2, p. 377, doi. 10.1007/s11011-018-0355-7
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- Publication type:
- Article
Antidepressant-like effects of the phosphodiesterase-4 inhibitor etazolate and phosphodiesterase-5 inhibitor sildenafil via cyclic AMP or cyclic GMP signaling in mice.
- Published in:
- Metabolic Brain Disease, 2014, v. 29, n. 3, p. 673, doi. 10.1007/s11011-014-9533-4
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- Publication type:
- Article
Piperphentonamine (PPTA) attenuated cerebral ischemia-induced memory deficits via neuroprotection associated with anti-apoptotic activity.
- Published in:
- Metabolic Brain Disease, 2012, v. 27, n. 4, p. 495, doi. 10.1007/s11011-012-9330-x
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- Publication type:
- Article
Effects of Xiaoyaosan on Stress-Induced Anxiety-Like Behavior in Rats: Involvement of CRF1 Receptor.
- Published in:
- Evidence-based Complementary & Alternative Medicine (eCAM), 2016, v. 2016, p. 1, doi. 10.1155/2016/1238426
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- Publication type:
- Article
GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway.
- Published in:
- Neural Plasticity, 2020, p. 1, doi. 10.1155/2020/8858415
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- Publication type:
- Article
Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling.
- Published in:
- Neuropsychopharmacology, 2014, v. 39, n. 7, p. 1763, doi. 10.1038/npp.2014.24
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- Publication type:
- Article
Antidepressant-like Profile and Reduced Sensitivity to Rolipram in Mice Deficient in the PDE4D Phosphodiesterase Enzyme
- Published in:
- Neuropsychopharmacology, 2002, v. 27, n. 4, p. 587
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- Publication type:
- Article
Fasudil in Combination With Bone Marrow Stromal Cells (BMSCs) Attenuates Alzheimer’s Disease-Related Changes Through the Regulation of the Peripheral Immune System.
- Published in:
- Frontiers in Aging Neuroscience, 2018, p. N.PAG, doi. 10.3389/fnagi.2018.00216
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- Publication type:
- Article
Imbalance of multiple neurotransmitter pathways leading to depression-like behavior and cognitive dysfunction in the triple transgenic mouse model of Alzheimer disease.
- Published in:
- Metabolic Brain Disease, 2023, v. 38, n. 7, p. 2465, doi. 10.1007/s11011-023-01242-2
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- Publication type:
- Article
Inhibition of phosphodiesterase-4 decreases ethanol intake in mice.
- Published in:
- Psychopharmacology, 2011, v. 218, n. 2, p. 331, doi. 10.1007/s00213-011-2290-8
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- Publication type:
- Article
Memory deficits and neurochemical changes induced by C-reactive protein in rats: implication in Alzheimer’s disease.
- Published in:
- Psychopharmacology, 2009, v. 204, n. 4, p. 705, doi. 10.1007/s00213-009-1499-2
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- Publication type:
- Article
Comparison of the effects of isoproterenol administered into the hippocampus, frontal cortex, or amygdala on behavior of rats maintained by differential reinforcement of low response rate.
- Published in:
- Psychopharmacology, 2001, v. 159, n. 1, p. 89, doi. 10.1007/s002130100889
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- Publication type:
- Article
Effects of rolipram on scopolamine-induced impairment of working and reference memory in the radial-arm maze tests in rats.
- Published in:
- Psychopharmacology, 2000, v. 150, n. 3, p. 311, doi. 10.1007/s002130000414
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- Publication type:
- Article
Phosphodiesterase 8 (PDE8): Distribution and Cellular Expression and Association with Alzheimer's Disease.
- Published in:
- Neurochemical Research, 2024, v. 49, n. 8, p. 1993, doi. 10.1007/s11064-024-04156-2
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- Publication type:
- Article
Synergistic effects of two naturally occurring iridoids in eliciting a rapid antidepressant action by up‐regulating hippocampal PACAP signalling.
- Published in:
- British Journal of Pharmacology, 2022, v. 179, n. 16, p. 4078, doi. 10.1111/bph.15847
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- Publication type:
- Article
Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice.
- Published in:
- Scientific Reports, 2015, p. 11332, doi. 10.1038/srep11332
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- Publication type:
- Article
RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects.
- Published in:
- British Journal of Pharmacology, 2013, v. 168, n. 4, p. 1001, doi. 10.1111/j.1476-5381.2012.02225.x
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- Publication type:
- Article
Baicalin attenuates amyloid β oligomers induced memory deficits and mitochondria fragmentation through regulation of PDE-PKA-Drp1 signalling.
- Published in:
- Psychopharmacology, 2022, v. 239, n. 3, p. 851, doi. 10.1007/s00213-022-06076-x
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- Publication type:
- Article
Phosphodiesterase 2 inhibitor Hcyb1 reverses corticosterone-induced neurotoxicity and depression-like behavior.
- Published in:
- Psychopharmacology, 2020, v. 237, n. 11, p. 3215, doi. 10.1007/s00213-019-05401-1
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- Publication type:
- Article
Inhibition of phosphodiesterase 2 by Bay 60-7550 decreases ethanol intake and preference in mice.
- Published in:
- Psychopharmacology, 2018, v. 235, n. 8, p. 2377, doi. 10.1007/s00213-018-4934-4
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- Publication type:
- Article
Cyclic nucleotide phosphodiesterases: potential therapeutic targets for alcohol use disorder.
- Published in:
- Psychopharmacology, 2018, v. 235, n. 6, p. 1793, doi. 10.1007/s00213-018-4895-7
- By:
- Publication type:
- Article
Attenuation of ethanol abstinence-induced anxiety- and depressive-like behavior by the phosphodiesterase-4 inhibitor rolipram in rodents.
- Published in:
- Psychopharmacology, 2017, v. 234, n. 20, p. 3143, doi. 10.1007/s00213-017-4697-3
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- Publication type:
- Article
The phosphodiesterase-4 inhibitor roflumilast decreases ethanol consumption in C57BL/6J mice.
- Published in:
- Psychopharmacology, 2017, v. 234, n. 16, p. 2409, doi. 10.1007/s00213-017-4631-8
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- Publication type:
- Article
Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior.
- Published in:
- Psychopharmacology, 2014, v. 231, n. 15, p. 2941, doi. 10.1007/s00213-014-3480-y
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- Publication type:
- Article
Identification of Phosphodiesterase-7A (PDE7A) as a Novel Target for Reducing Ethanol Consumption in Mice.
- Published in:
- International Journal of Neuropsychopharmacology, 2024, v. 27, n. 8, p. 1, doi. 10.1093/ijnp/pyae032
- By:
- Publication type:
- Article
Rolipram Ameliorates Memory Deficits and Depression-Like Behavior in APP/PS1/tau Triple Transgenic Mice: Involvement of Neuroinflammation and Apoptosis via cAMP Signaling.
- Published in:
- International Journal of Neuropsychopharmacology, 2023, n. 9, p. 585, doi. 10.1093/ijnp/pyad042
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- Publication type:
- Article
The Construction and Application of a New Screening Method for Phosphodiesterase Inhibitors.
- Published in:
- Biosensors (2079-6374), 2024, v. 14, n. 5, p. 252, doi. 10.3390/bios14050252
- By:
- Publication type:
- Article
Reduced phosphodiesterase-2 activity in the amygdala results in anxiolytic-like effects on behavior in mice.
- Published in:
- 2019
- By:
- Publication type:
- journal article
Comparative study on effects of Xiaoyao Powder (逍遥散) and its modified prescription on plasma metabolomics of rats with chronic immobilization stress.
- Published in:
- 2013
- By:
- Publication type:
- Journal Article
Comparative study on effects of Xiaoyao Powder (逍遥散) and its modified prescription on plasma metabolomics of rats with chronic immobilization stress.
- Published in:
- Chinese Journal of Integrative Medicine, 2013, v. 19, n. 8, p. 610, doi. 10.1007/s11655-012-1092-0
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- Publication type:
- Article