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- Title
Acanthamoeba meningoencephalitis causing secondary hemophagocytic lymphohistiocytosis in an immunocompetent patient: A first case report.
- Authors
Chowdhury, Mohit; Prakash, Prithivi Raaj; Singh, Amandeep; Jorwal, Pankaj; Das, Sumanta; Soneja, Manish
- Abstract
Acanthamoeba is a rare cause of granulomatous amoebic encephalitis (GAE) associated with high mortality. There have been few case reports of Acanthamoeba meningoencephalitis worldwide. Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory condition caused by abnormally active macrophages and cytotoxic T lymphocytes; its secondary form is due to infections or malignancies. However, HLH is rather an unknown complication of GAE. We describe an unusual and previously unreported case of Acanthamoeba meningoencephalitis in a young immunocompetent female culminating in secondary HLH.
- Subjects
HEMOPHAGOCYTIC lymphohistiocytosis; ACANTHAMOEBA; MENINGOENCEPHALITIS; CYTOTOXIC T cells; MACROPHAGE activation syndrome
- Publication
Journal of the Royal College of Physicians of Edinburgh, 2023, Vol 53, Issue 1, p23
- ISSN
1478-2715
- Publication type
Article
- DOI
10.1177/14782715221149709