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- Title
Factors that Predict Neutropenia in Korean Patients with Advanced Urothelial Cancer after Cisplatin-Based Systemic Chemotherapy.
- Authors
Whi-An Kwon; Tae Hoon Oh; Jea Whan Lee; Ill Young Seo; Sung Chol Park
- Abstract
Purpose: The aim of this study was to identify factors that can be used to predict severe neutropenia (grade 3 or higher) in patients with advanced urothelial cancer after cisplatin-based systemic chemotherapy. Materials and Methods: The study examined 79 Korean patients with advanced urothelial cancer who were treated with several cycles of cisplatin-based systemic chemotherapy from May 2006 to May 2015. Risk factors for neutropenia (grade 3 or higher) and for the occurrence of neutropenia (grade 3 or higher) during the first cycle of chemotherapy were examined. Result: Thirty-six out of the 79 patients (45.6%) developed neutropenia at grade 3 or higher during the first cycle of cisplatin-based systemic chemotherapy: 18 (22.7%) of these experienced grade 3 neutropenia and 18 (22.7%) experienced grade 4. Multivariate analysis identified pretreatment neutrophil counts (P = .001) as the only significant factor predictive for severe neutropenia. Conclusion: The pretreatment neutrophil count was found to be the factor that poses a significant and independent risk in development of severe neutropenia induced by applying cisplatin-based systemic chemotherapy to patients with advanced urothelial cancer.
- Subjects
NEUTROPENIA; TRANSITIONAL cell carcinoma; CISPLATIN; CANCER chemotherapy; CANCER patients; THERAPEUTICS
- Publication
Urology Journal, 2018, Vol 15, Issue 4, p168
- ISSN
1735-1308
- Publication type
Article