We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Rheumatoid Factor, Anti-Cyclic Citrullinated Peptide Antibody, C-Reactive Protein, and Erythrocyte Sedimentation Rate for the Clinical Diagnosis of Rheumatoid Arthritis.
- Authors
Rongchun Shen; Xiaojuan Ren; Rongrong Jing; Xianjuan Shen; Jianping Chen; Shaoqing Ju; Chunlan Yang
- Abstract
Objective: To explore the value of rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) antibody, C-reactive protein (CRP), and the erythrocyte sedimentation rate (ESR) in the diagnosis of rheumatoid arthritis (RA). Methods: Using rate nephelometry, chemiluminescence microparticle immunoassay (CMIA), and Westergren sedimentation rate testing, we detected RF, anti-CCP antibody, CRP, and ESR in 134 patients with RA and 50 healthy control individuals. Results: We observed significant differences in RF, anti-CCP antibody, CRP, and ESR concentrations between the RA and control groups (P <.01). The sensitivity, specificity and accuracy in the diagnosis of RA were 91.0%, 74.4%, and 87.0%, respectively, for RF; 88.0%, 90.4%, and 88.1%, respectively, for anti-CCP antibody; and 90.2%, 83.3%, and 89.5%, respectively, for the detection of RA via the combination of RF and anti-CCP antibody. Conclusion: Anti-CCP is more specific than the other parameters we reviewed for the diagnosis of RA. Combined detection of the 4 parameters is beneficial when confirming a diagnosis of RA.
- Subjects
CHINA; RHEUMATOID arthritis diagnosis; AUTOANTIBODIES; BLOOD sedimentation; C-reactive protein; CHI-squared test; DIAGNOSTIC errors; IMMUNOASSAY; IMMUNOGLOBULINS; LONGITUDINAL method; PHOTOMETRY; PROBABILITY theory; T-test (Statistics); PREDICTIVE tests; DATA analysis software; DESCRIPTIVE statistics
- Publication
Laboratory Medicine, 2015, Vol 46, Issue 3, p226
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1309/LMZYTSO5RHIHV93T