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- Title
Identification of Anti-Plasmodium falciparum Antibodies in Human Breast Milk.
- Authors
Leke, R. G. F.; Ndansi, R.; Southerland, N. J.; Quakyi, I. A.; Taylor, D. W.
- Abstract
Malarial infections are rarely observed in neonates. It has been postulated that some immunity may be passively transferred during nursing, but anti-malarial antibodies (Abs) have not been detected m human milk. In this study, milk samples, collected 2-14 days after parturition from women at the Central Maternity Hospital, Yaounde, were evaluated for total IgG and IgA antibody levels by radial diffusion, protein composition by SDS-PAGE, anti-malarial antibodies using an isotype-specific immunofluorescence assay, and the ability to immunoprecipitate Plasmodium falciparum antigens metabolically labelled with 35S-methionine. Results showed that anti-P. falciparum antibodies were present in breast milk, and that paired milk and serum samples from individual women contained Abs that recognized similar malarial antigens.
- Subjects
IMMUNOGLOBULINS; PLASMODIUM falciparum; MALARIA; BREAST milk; IMMUNITY; ANTIGENS
- Publication
Scandinavian Journal of Immunology, 1992, Vol 36, p17
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1992.tb01612.x