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- Title
Lymphosonographic sentinel node biopsy of the supraglottis in a swine model
- Authors
Curry, Joseph M.; Grindle, Christopher R.; Merton, Daniel A.; Goldberg, Barry B.; Rosen, David; Pribitkin, Edmund A.
- Abstract
Objective: To test the feasibility of a novel contrast-enhanced ultrasound (CEUS) technique, or lymphosonography, for sentinel node biopsy (SNB) of the supraglottis in a porcine model. Study Design and Setting: In this prospective, nonrandomized animal study, blue dye and ultrasound contrast agent were injected into the supraglottis in seven 50-kg Yorkshire swine. Transcutaneous CEUS was used to identify real-time lymphatic flow of contrast through lymph channels (LC) to the sentinel lymph node (SLN). SNB was carried out, visually identifying a blue node, with the assistance of intraoperative CEUS. Bilateral modified radical neck dissections were performed to search for any residual contrast-positive or blue SLNs. Results: In each case, at least one SLN was identified by preoperative CEUS. A total of 12 nodes were identified on preoperative CEUS, and 11 of 12 nodes were stained with blue dye (91.7%). No residual blue or contrast-positive nodes were identified on neck dissection. Conclusions: Lymphosonographic SNB of the supraglottis in a porcine model is technically feasible, and yields results comparable to traditional blue dye–guided techniques. No “shine-through” effect or nonsequential nodal enhancement occurred. This technique holds promise for sentinel node biopsy and allows a novel method for in vivo investigation of the lymphatic system.
- Subjects
CONTRAST-enhanced ultrasound; GLOTTIS; BIOPSY; LARYNGEAL diseases; LYMPHATICS; LABORATORY swine; DISSECTION; LYMPH nodes; DIAGNOSIS
- Publication
Otolaryngology-Head & Neck Surgery, 2008, Vol 139, Issue 6, p798
- ISSN
0194-5998
- Publication type
Article
- DOI
10.1016/j.otohns.2008.08.029