We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Is Aspartate an Excitatory Neurotransmitter?
- Authors
Herring, Bruce E.; Silm, Katlin; Edwards, Robert H.; Nicoll, Roger A.
- Abstract
Recent evidence has resurrected the idea that the amino acid aspartate, a selective NMDA receptor agonist, is a neurotransmitter. Using a mouse that lacks the glutamate-selective vesicular transporter VGLUT1, we find that glutamate alone fully accounts for the activation of NMDAreceptors at excitatory synapses in the hippocampus. This excludes a role for aspartate and, by extension, a recently proposed role for the sialic acid transporter sialin in excitatory transmission.
- Subjects
ASPARTATES; ASPARTIC acid; AMINO acid metabolism; HIPPOCAMPUS (Brain); SIALIC acids
- Publication
Journal of Neuroscience, 2015, Vol 35, Issue 28, p10168
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.0524-15.2015