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- Title
Editorial: Improved Efficacy of Biological Maintenance Therapy in “Early” Compared With “Late” Crohn's Disease: Strike While the Iron Is Hot With Anti-TNF Agents?
- Authors
Ananthakrishnan, Ashwin N.; Binion, David G.
- Abstract
There is growing interest in the use of biologic therapy early in the course of Crohn's disease. In this issue, Schreiber et al. use data from the PRECISE trials to demonstrate a greater response to certolizumab in patients with shorter duration of disease. This suggests that early treatment prior to the occurrence of significant tissue remodeling and irreversible cumulative bowel damage may result in better outcomes. This editorial describes the data published so far on the correlation between disease duration and treatment response and examines the potential benefits to such treatment algorithms.
- Subjects
DRUG efficacy; CROHN'S disease; TUMOR necrosis factor receptors; CLINICAL trials; ALGORITHMS; THERAPEUTICS
- Publication
American Journal of Gastroenterology (Springer Nature), 2010, Vol 105, Issue 7, p1583
- ISSN
0002-9270
- Publication type
Article
- DOI
10.1038/ajg.2010.98