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- Title
Evaluation of endoscopic hemostasis with metallic hemoclips for bleeding gastric ulcer: comparison with endoscopic injection of absolute ethanol in a prospective, randomized study
- Authors
Shimoda, Ryo; Iwakiri, Ryuichi; Sakata, Hiroyuki; Ogata, Shinichi; Kikkawa, Atsushi; Ootani, Hibiki; Oda, Kayoko; Ootani, Akifumi; Tsunada, Seiji; Fujimoto, Kazuma
- Abstract
: ObjectiveAlthough metallic hemoclips have been used for hemostasis of bleeding ulcer, there have been few prospective trials to evaluate their efficacy. In this study, a prospective, randomized trial was performed to evaluate endoscopic hemoclipping for bleeding gastric ulcer in comparison with endoscopic injection of absolute ethanol.: MethodsDuring the period 1995–1998, 126 gastric ulcer patients with bleeding or nonbleeding visible vessel were considered for entry. They were randomly assigned to one of three groups: endoscopic hemostasis performed with injection of absolute ethanol (group I, n = 42), hemoclipping (group II, n = 42), and a combination of the two methods (group III, n = 42).: ResultsThe permanent hemostatic rate was 85.7% in group I, 90.5% in group II, and 92.9% in group III. The mean volume of blood transfusion was 313 ± 77 ml in group I, 274 ± 54 ml in group II, and 163 ± 42 ml in group III, which was significantly less than in groups I or II (p < 0.05). No patients required emergency surgery. Five patients died within a month after initial hemostasis as a result of unrelated conditions.: ConclusionsEndoscopic hemostasis with hemoclips for bleeding gastric ulcer was as effective and safe as that with injection of absolute ethanol, and a combination of ethanol injection and hemoclips did not result in a great advantage over the two individual procedures.
- Subjects
HEMOSTASIS; ULCERS; ENDOSCOPY; CLINICAL trials
- Publication
American Journal of Gastroenterology (Springer Nature), 2003, Vol 98, Issue 10, p2198
- ISSN
0002-9270
- Publication type
Article
- DOI
10.1111/j.1572-0241.2003.07692.x