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- Title
Enhanced preattentive central nervous system reactivity in irritable bowel syndrome
- Authors
Berman, Steven M.; Naliboff, Bruce D.; Chang, Lin; FitzGerald, Leah; Antolin, Tim; Camplone, Art; Mayer, Emeran A.
- Abstract
OBJECTIVE:Irritable bowel syndrome (IBS) is a common functional disorder characterized by enhanced perceptual sensitivity and hypervigilance toward afferent signals from the viscera. We hypothesize that the increased responsiveness of IBS patients is a generalized phenomenon applying to stimuli other than visceral and attempt to demonstrate increased responsiveness to sounds as measured by the P1 scalp potential.METHODS:Event-related potentials were recorded from IBS patients and control subjects in an auditory task requiring detection of rare pitch targets in a designated ear. Visual words served as targets in an additional block.RESULTS:Compared to control subjects, IBS patients displayed a robust increase in the amplitude of the P1 scalp potential elicited by both attended and unattended sounds.CONCLUSIONS:Enhanced P1 indicates preattentive central nervous system dishabituation in response to repeated sounds. A generalized preattentive increase in central nervous system reactivity may be a feature that IBS shares with several anxiety disorders that frequently co-occur in these patients.
- Subjects
IRRITABLE colon; CENTRAL nervous system; VISCERA
- Publication
American Journal of Gastroenterology (Springer Nature), 2002, Vol 97, Issue 11, p2791
- ISSN
0002-9270
- Publication type
Article
- DOI
10.1111/j.1572-0241.2002.07024.x