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- Title
Variations in Sleep Characteristics and Glucose Regulation in Young Adults With Type 1 Diabetes.
- Authors
Griggs, Stephanie; Grey, Margaret; Stroh, Kingman P.; Crawford, Sybil L.; Margevicius, Seunghee; Kashyap, Sangeeta R.; Li, Chiang-Shan R.; Rajagopalan, Sanjay; Hickman Jr., Ronald L.
- Abstract
Context: Short sleep duration and sleep disruptions are associated with impaired glucoregulation in type 1 diabetes (T1D). However, the mechanistic pathways between sleep and glucose variability remain unclear. Objective: To determine within- and between-person associations between objective sleep-wake characteristics and glucose variability indices. Methods: Multilevel models were used to analyze concurrent sleep and glucose patterns over 7 days in 42 young adults with T1D in their natural home environment. Young adults with T1D (mean age 22.2 ± 3.0 years, HbA1c 7.2%, 32.6% male) for at least 6 months with no other medical or major psychiatric comorbidity were included. Sleep-wake characteristics were measured via wrist actigraphy and glucose variability indices via a continuous glucose monitor (CGM). Results: Lower sleep efficiency predicted higher glucose variability (less time in range ß = 0.011 and more time in hyperglycemia ß = -0.011) within-person. A longer wake after sleep onset and more sleep disruptions were associated with higher glucose variability between persons (ß = 0.28 and 0.31). Higher glucose variability predicted poorer sleep within-person (delayed bedtime, waketime, mid-sleep time, and lower sleep efficiency), while higher glucose variability was associated with poorer sleep and more sleep disruptions between persons (lower sleep efficiency, longer wake after sleep onset, and a higher sleep fragmentation index). Conclusion: Clinicians can address the reciprocal nature of the sleep-glucose relationship by optimizing sleep and targeting efforts toward a euglycemic range overnight. Sleep habits are a modifiable personal target in diabetes care.
- Subjects
GLUCOSE; YOUNG adults; TYPE 1 diabetes
- Publication
Journal of Clinical Endocrinology & Metabolism, 2022, Vol 107, Issue 3, p1085
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/clinem/dgab771