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- Title
An Integrative Thrombosis Network: Visualization and Topological Analysis.
- Authors
Kong, Xiangjun; Zhou, Wenxia; Wan, Jian-Bo; Zhang, Qianru; Ni, Jingyun; Hu, Yuanjia
- Abstract
A comprehensive understanding of the integrative nature of the molecular network in thrombosis would be very helpful to develop multicomponent and multitarget antithrombosis drugs for use in traditional Chinese medicine (TCM). This paper attempts to comprehensively map the molecular network in thrombosis by combining platelet signaling, the coagulation cascade, and natural clot dissolution systems and to analyze the topological characteristics of the network, including the centralities of nodes, network modules, and network robustness. The results in this research advance understanding of functions of proteins in the thrombosis network and provide a reference for predicting potential therapeutic antithrombotic targets and evaluating their influence on the network.
- Subjects
FIBRINOLYTIC agents; BLOOD coagulation; CELLULAR signal transduction; CHINESE medicine; THROMBOSIS; BIOINFORMATICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2015, Vol 2015, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2015/265303