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- Title
Effects of Electroacupuncture on N- Methyl-D-aspartate Receptor-Related Signaling Pathway in the Spinal Cord of Normal Rats.
- Authors
Ha-Neui Kim; Yu-Ri Kim; Ji-Yeon Jang; Hwa-Kyoung Shin; Byung-Tae Choi
- Abstract
This study examined the influence of the N-methyl-D-aspartate receptor (NMDAR) on the modulation of related spinal signaling after electroacupuncture (EA) treatment in normal rats. Bilateral 2Hz EA stimulations (1-2-3.0mA) were delivered at acupoints corresponding to Zusanli (ST36) and Sanyinjiao (SP6) in men for 30 min. Thermal sensitization was strongly inhibited by EA, but this analgesia was reduced by preintrathecal injection of the NMDAR antagonist, MK801. Phosphorylation of the NMDAR NR2B subunit, cA MP response element-binding protein (CREB), and especially phosphatidylinositol 3-kinase (PI3K) were significantly induced by EA. However, these marked phosphorylations were not observed in MK801-pretreated rats. EA analgesia was reduced by preintrathecal injection with the calcium chelators Quin2 and T MB8, similar to the results evident using MK801. Phosphorylation of PI3K and CREB induced by EA was also inhibited by T MB8. Calcium influx by NMDAR activation may play an important role in EA analgesia of normal rats through the modulation of the phosphorylation of spinal PI3K and CREB.
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2012, Vol 2012, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2012/492471