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- Title
Cyanidin 3- O-glucoside Isolated from Lonicera caerulea Fruit Improves Glucose Response in INS-1 Cells by Improving Insulin Secretion and Signaling.
- Authors
Lee, Dahae; Ham, Jungyeob; Kang, Ki Sung; Lee, Hae-Jeung
- Abstract
Cyaniding 3- O-glucoside is a flavonoid compound isolated from the fruits of the Lonicera caerulea. In the present study, we investigated the effects of L. caerulea extract and its active component cyaniding 3- O-glucoside on insulin release in INS-1 cells. L. caerulea extract and cyanidin 3- O-glucoside activated the secretion of insulin that lead to diminished glucose production in INS-1 cells. Cyanidin 3- O-glucoside also enhanced the phosphorylation of insulin receptor, insulin receptor substrate 1, and phosphoinositide 3-kinase protein expressions in INS-1 cells. These results suggest that cyanidin 3- O-glucoside is an active component of L. caerulea that enhances insulin production and activates insulin signaling.
- Subjects
HONEYSUCKLES; PLANT extracts; CYANIDIN; GLUCOSIDES; INSULIN; CELLULAR signal transduction
- Publication
Bulletin of the Korean Chemical Society, 2016, Vol 37, Issue 12, p2015
- ISSN
0253-2964
- Publication type
Article
- DOI
10.1002/bkcs.11017