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- Title
A Synthesis of Novel Pyrazolylthienopyrimidine Derivatives as IL-6/STAT3 Inhibitors.
- Authors
Sung Min Kim; Seung Woong Lee; Yang-Heon Song
- Abstract
The article provides information on a study which examined the synthesis and biological activity of novel pyrazolylthienopyrimidine derivatives as interleukin (IL)-6/signal transducer and signal activator of transcription-3 (STAT3) inhibitor. Topics discussed include the role of IL-6 as a pro-inflammatory cytokine and reaction optimization for the regio-selective formation of 1,5-isomer.
- Subjects
PYRAZOLYL compounds; PYRAZOLE derivatives; PYRIMIDINE derivatives; INTERLEUKIN-6; STAT proteins; CYTOKINES
- Publication
Bulletin of the Korean Chemical Society, 2014, Vol 35, Issue 9, p2859
- ISSN
0253-2964
- Publication type
Article
- DOI
10.5012/bkcs.2014.35.9.2859