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- Title
Hemodynamic Traveling Waves in Human Visual Cortex.
- Authors
Aquino, Kevin M.; Schira, Mark M.; Robinson, P. A.; Drysdale, Peter M.; Breakspear, Michael
- Abstract
Functional MRI (fMRI) experiments rely on precise characterization of the blood oxygen level dependent (BOLD) signal. As the spatial resolution of fMRI reaches the sub-millimeter range, the need for quantitative modelling of spatiotemporal properties of this hemodynamic signal has become pressing. Here, we find that a detailed physiologically-based model of spatiotemporal BOLD responses predicts traveling waves with velocities and spatial ranges in empirically observable ranges. Two measurable parameters, related to physiology, characterize these waves: wave velocity and damping rate. To test these predictions, high-resolution fMRI data are acquired from subjects viewing discrete visual stimuli. Predictions and experiment show strong agreement, in particular confirming BOLD waves propagating for at least 5-10 mm across the cortical surface at speeds of 2-12 mm s-1. These observations enable fundamentally new approaches to fMRI analysis, crucial for fMRI data acquired at high spatial resolution.
- Subjects
VISUAL cortex; HEMODYNAMICS; MAGNETIC resonance imaging; PARAMETER estimation; THEORY of wave motion; DISCRETE systems
- Publication
PLoS Computational Biology, 2012, Vol 8, Issue 3, p1
- ISSN
1553-734X
- Publication type
Article
- DOI
10.1371/journal.pcbi.1002435