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- Title
Genomic landscape of treatment‐naïve urological cancers using next‐generation sequencing‐based panel test in the Japanese population.
- Authors
Mizutani, Kosuke; Hirade, Kouseki; Sugiyama, Seiji; Kato, Yasutaka; Nishihara, Hiroshi; Ishihara, Satoshi
- Abstract
Keywords: genome profiling; next-generation sequencing; prostate cancer; renal cell carcinoma; urothelial carcinoma EN genome profiling next-generation sequencing prostate cancer renal cell carcinoma urothelial carcinoma 909 911 3 08/04/22 20220801 NES 220801 Abbreviations & Acronyms IQR interquartile range NGS next-generation sequencing PC prostate cancer RCC renal cell carcinoma TMB tumor mutational burden UC urothelial carcinoma The top three urologic cancers in terms of mortality are PC (3.8%), bladder cancer (2.1%), and kidney cancer (2.1%) among all cancers in 2020.1 The determination of therapeutic sensitivity based on genomic alteration has been used to improve therapeutic effects in cancer patients.2 Cancer results from the accumulation of mutations; thus, genomic testing using NGS has been widely applied in the evaluation of clinical utility.3,4 It is reported that genomic alterations can be raised during the development of therapeutic resistance.5 Therefore, knowledge of the landscape of genomic alterations in treatment-naïve cancers would be useful to understand whether the genomic alteration is induced by treatment. Genomic landscape of treatment-naïve urological cancers using next-generation sequencing-based panel test in the Japanese population A targeted amplicon exome sequencing-based panel test was performed with a cancer gene panel consisting of 160 cancer-related genes.6 A list of the genes and detailed methods were presented in Table S1.
- Subjects
JAPANESE people; PROSTATE cancer; CIRCULATING tumor DNA; RENAL cell carcinoma; TRANSITIONAL cell carcinoma; BLADDER cancer
- Publication
International Journal of Urology, 2022, Vol 29, Issue 8, p909
- ISSN
0919-8172
- Publication type
Article
- DOI
10.1111/iju.14927