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- Title
Transplantation of kidneys from uncontrolled donation after circulatory determination of death: comparison with brain death donors with or without extended criteria and impact of normothermic regional perfusion.
- Authors
Demiselle, Julien; Augusto, Jean-François; Videcoq, Michel; Legeard, Estelle; Dubé, Laurent; Templier, François; Renaudin, Karine; Sayegh, Johnny; Karam, Georges; Blancho, Gilles; Dantal, Jacques
- Abstract
The aim of this study was to compare the outcomes of kidney transplants from uncontrolled DCD ( uDCD) with kidney transplants from extended ( ECD) and standard criteria donors ( SCD). In this multicenter study, we included recipients from uDCD ( n = 50), and from ECD ( n = 57) and SCD ( n = 102) who could be eligible for a uDCD program. We compared patient and graft survival, and kidney function between groups. To address the impact of preservation procedures in uDCD, we compared in situ cold perfusion ( ICP) with normothermic regional perfusion ( NRP). Patient and graft survival rates were similar between the uDCD and ECD groups, but were lower than the SCD group ( P < 0.01). Although delayed graft function ( DGF) was more frequent in the uDCD group (66%) than in the ECD (40%) and SCD (27%) groups ( P = 0.08 and P < 0.001), graft function was comparable between the uDCD and ECD groups at 3 months onwards post-transplantation. The use of NRP in the uDCD group ( n = 19) was associated with a lower risk of DGF, and with a better graft function at 2 years post-transplantation, compared to ICP- uDCD ( n = 31) and ECD. In conclusion, the use of uDCD kidneys was associated with post-transplantation results comparable to those of ECD kidneys. NRP preservation may improve the results of uDCD transplantation.
- Subjects
KIDNEY transplantation; ORGAN donors; ORGAN donation; KIDNEY function tests; GRAFT rejection
- Publication
Transplant International, 2016, Vol 29, Issue 4, p432
- ISSN
0934-0874
- Publication type
Article
- DOI
10.1111/tri.12722