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- Title
Impaired wound healing and expansion of a large ulcer after bevacizumab with paclitaxel for skin metastases from breast cancer: report of a case.
- Authors
Kijima, Yuko; Yoshinaka, Heiji; Hirata, Munetsugu; Nakajo, Akihiro; Arima, Hideo; Shinden, Yoshiaki; Ijichi, Tetsuya; Eguchi, Yuka; Okumura, Hiroshi; Uenosono, Yoshikazu; Kurahara, Hiroshi; Ishigami, Sumiya; Natsugoe, Shoji
- Abstract
A 48-year-old Japanese woman was found to have local recurrence of breast cancer in the chest wall following neoadjuvant chemotherapy, total mastectomy with axillary lymphadenectomy, postoperative radiation therapy to the chest wall, and adjuvant systemic therapy using trastuzumab. As a third line of treatment after recurrence, bevacizumab with paclitaxel was initiated for several metastatic lesions on the skin of the chest wall, left internal costal lymph nodes, and right axillary lymph nodes. The wound on the chest wall continued to expand in diameter and depth after the third course of bevacizumab with paclitaxel until the rib was exposed. After stopping the bevacizumab, granulation tissue expanded and by 3 months, had covered the bottom of the ulcer. The patient died soon thereafter, despite systemic chemotherapy with eribulin; however, there was no further bleeding from the ulcer on the chest wall or the exposed ribs.
- Subjects
SKIN cancer; CANCER treatment; BEVACIZUMAB; PACLITAXEL; WOUND healing; ULCERS; BREAST cancer; METASTASIS; CANCER chemotherapy
- Publication
Surgery Today, 2015, Vol 45, Issue 4, p498
- ISSN
0941-1291
- Publication type
Article
- DOI
10.1007/s00595-014-0912-6