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- Title
Comprehensive model for simultaneous MRI determination of perfusion and permeability using a blood-pool agent in rats rhabdomyosarcoma.
- Authors
de Bazelaire, Cedric; Siauve, Nathalie; Fournier, Laure; Frouin, Frederique; Robert, Philippe; Clement, Olivier; Kerviler, Eric; Cuenod, Charles Andre; de Kerviler, Eric
- Abstract
To present a new compartmental analysis model developed to simultaneously measure tissue perfusion and capillary permeability in a tumor using MRI and a macromolecular contrast medium. Rhadomyosarcomas were implanted subcutaneously in 20 rats and studied by 1.5-T MRI using a fast gradient echo sequence (2D fast SPGR TR/TE/alpha 13 ms/1.2 ms/60 degrees ) after injection of a macromolecular contrast medium. The left ventricle and tumor signal intensities were converted into concentrations and modeled using compartmental analysis, yielding tumor perfusion F, distribution volume Vdistribution, volume transfer constant Ktrans, rate constant of influx kpe, and initial extraction (fraction) E. Tumor perfusion was F=43+/-29 ml.min-1.100 g-1. The permeability study allowed the measurement of kpe=0.37+/-0.12 min-1 and Ktrans=0.01+/-0.0031 min-1. The blood volume could be assimilated to the distribution volume (Vdistribution=2.9+/-1.01%) since the capillary leakage was small. The simultaneous assessment of perfusion and permeability allowed quantification of the initial extraction (fraction) E=2.34+/-1.05%. Quantification of both tumor perfusion and capillary leakage is feasible using MRI using a macromolecular blood pool agent. The method should improve tumor characterization.
- Subjects
PERFUSION; BODY fluids; TUMORS; PATHOLOGY; MAGNETIC resonance imaging; DIAGNOSTIC imaging; ALGORITHMS; ANIMAL experimentation; BIOLOGICAL models; COMPARATIVE studies; COMPUTER simulation; HETEROCYCLIC compounds; INDICATOR dilution; RESEARCH methodology; MEDICAL cooperation; COMPUTERS in medicine; ORGANOMETALLIC compounds; PERMEABILITY; RATS; RESEARCH; RESEARCH evaluation; RHABDOMYOSARCOMA; EVALUATION research; CONTRAST media; PATHOLOGIC neovascularization
- Publication
European Radiology, 2005, Vol 15, Issue 12, p2497
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-005-2873-z