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- Title
Salivary levels of hBDs in children and adolescents with type 1 diabetes mellitus and gingivitis.
- Authors
Yilmaz, Dogukan; Yilmaz, Neslihan; Polat, Recep; Nissilä, Verneri; Aydın, Elif Gül; Rautava, Jaana; Gürsoy, Mervi; Gürsoy, Ulvi Kahraman
- Abstract
Objectives: Type 1 diabetes mellitus (T1DM), a chronic autoimmune disease characterized by insulin deficiency, is related to periodontal diseases in children and adolescents. Our aim was to profile salivary human beta-defensin (hBD)-2 and hBD-3 concentrations in relation to periodontal and T1DM status in children and adolescent populations. Material and methods: Unstimulated saliva samples were collected from 66 participants including periodontally healthy T1DM patients (T1DM + C; n = 18), T1DM patients with gingivitis (T1DM + G; n = 20), systemically and periodontally healthy individuals (SH + C: n = 15), and systemically healthy gingivitis patients (SH + G; n = 13). Full mouth plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded. Salivary hBD-2 and hBD-3 concentrations were evaluated by sandwich ELISA method. A p value of < 0.05 was considered statistically significant. Results: Salivary hBD-3 concentrations were lower in T1DM groups in comparison to systemically healthy counterparts (SH + G vs. T1DM + G; p < 0.001 and SH + C vs. T1DM + C; p < 0.001). Salivary hBD-2 levels did not differ between related groups. The difference in hBD-3 concentrations between T1DM and control groups was still significant (p = 0.008) after being adjusted for PI%, BOP%, and age. Conclusion: In the limits of study, T1DM patients were found to have decreased salivary hBD-3 concentrations, regardless of their gingival inflammatory status. Clinical relevance: Altered salivary hBD-3 concentration can partly explain why diabetic children are more prone to periodontal diseases.
- Subjects
TYPE 1 diabetes; GINGIVITIS; JUVENILE diseases; TEENAGERS; PERIODONTAL disease
- Publication
Clinical Oral Investigations, 2022, Vol 26, Issue 7, p4897
- ISSN
1432-6981
- Publication type
Article
- DOI
10.1007/s00784-022-04457-2