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- Title
Prophylactic submucosal saline-adrenaline injection in colonoscopic polypectomy: prospective randomized study.
- Authors
Dobrowolski, S; Dobosz, M; Babicki, A; Dymecki, D; Hać, S
- Abstract
<bold>Background: </bold>Endoscopic polypectomy is a standard method of treatment of gastrointestinal polyps, but is associated with substantial risk of complications. The most common is hemorrhage, the rate of which varied between 0.3%, and 6%. Various prophylactic techniques have been used to reduce this incidence. The aim of this study was to establish whether the prophylactic injection of adrenaline-saline solution reduces the risk of postpolypectomy bleeding in colonoscopic polypectomy.<bold>Methods: </bold>Between May 2000 and June 2002, patients with colorectal polyps of size > or =1 cm were randomized to receive submucosal epinephrine injection (group A) or no injection (group B). The polypectomies were carried out using the conventional method. In group A, epinephrine (1/10,000) was injected into the stalk or base of the polyp. The patients were observed for complications.<bold>Results: </bold>A total of 69 patients with 100 polyps were enrolled in this study: n = 50 in group A, and n = 50 in group B, according to randomization. There were a total of nine episodes of postpolypectomy hemorrhage, one in the epinephrine group and eight in the control group (1/50 vs 8/50, p < 0.05). The bleeding correlated with the size of the polyps and the diameter of the stalks.<bold>Conclusions: </bold>Epinephrine injection prior to colonoscopic polypectomy is effective in preventing bleeding.
- Subjects
HEMORRHAGE prevention; HALOTHERAPY; PREVENTION of surgical complications; ELECTROCOAGULATION (Medicine); ADENOCARCINOMA; ADRENALINE; BLOOD transfusion; CLINICAL trials; COLON tumors; COLONOSCOPY; COMPARATIVE studies; HEMORRHAGE; HEMOSTATICS; INJECTIONS; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; PREANESTHETIC medication; RECTUM tumors; RESEARCH; SALT; SURGICAL complications; EVALUATION research; RANDOMIZED controlled trials; COLON polyps; ADENOMATOUS polyps; SURGICAL blood loss; THERAPEUTICS
- Publication
Surgical Endoscopy & Other Interventional Techniques, 2004, Vol 18, Issue 6, p990
- ISSN
1866-6817
- Publication type
journal article
- DOI
10.1007/s00464-003-9214-6