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- Title
Research on the mechanism of Chaihu Huangqin medicine based on integrated pharmacology to improve the clinical symptoms of COVID-19.
- Authors
Huan-Le Fang; Bei-Bei Bie; Ying Mu; Rong-Li Liu; Yan-Bin Chen
- Abstract
Objective: Novel coronavirus (COVID-19) was used to improve the clinical symptoms of the new type coronavirus (LV), based on integrated pharmacology. Methods: TCMIP v2.0 was used to predict the key target and action pathway of Bupleurum baicalensis Georgi in improving the clinical symptoms of covid-19. The multi-dimensional network diagram of "drug pair active component key target action pathway" was drawn to explore its action mechanism from the molecular level. Results: Bupleurum and Scutellaria baicalensis could regulate IL signaling pathway and clec7a (a member of C-type lectin domain 7 family). Inflammatory pathway, immune stress and other related signaling pathways can inhibit activated cytokines, alleviate excessive immune response, eliminate inflammation, and resist virus. In addition, the core targets of Bupleurum baicalensis baicalensis Georgi: nuclear factor kB (NFKB2, NFKB1), interleukin (IL-6, IL-1B), toll like receptor 4 (TLR4), tumor necrosis factor (TNF) and so on are mostly induced by inflammation It is related to body damage. Bupleurum and scutellaria have the clinical effects of anti-inflammatory, antiviral, strengthening immunity, inhibiting pulmonary fibrosis and so on. Conclusion: Radix Bupleuri Scutellariae can be used to treat covid-19 by multi-channel, multi-target and multi ring. The results of this study provide a theoretical basis for Bupleurum Scutellaria to improve the use of COVID-19.
- Subjects
COVID-19 pandemic; PHARMACOLOGY; PUBLIC health; CELL communication; INFLAMMATION
- Publication
Journal of Hainan Medical University, 2020, Vol 26, Issue 12, p15
- ISSN
1007-1237
- Publication type
Article