We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Association Analyses of Insulin Signaling Pathway Gene Polymorphisms With Healthy Aging and Longevity in Americans of Japanese Ancestry.
- Authors
Morris, Brian J.; Donlon, Timothy A.; He, Qimei; Grove, John S.; Masaki, Kamal H.; Elliott, Ayako; Willcox, D. Craig; Willcox, Bradley J.
- Abstract
Evidence from model organisms suggests that the insulin/IGF-1 signaling pathway has an important, evolutionarily conserved influence over rate of aging and thus longevity. In humans, the FOXO3 gene is the only widely replicated insulin/IGF-1 signaling pathway gene associated with longevity across multiple populations. Therefore, we conducted a nested case–control study of other insulin/IGF-1 signaling genes and longevity, utilizing a large, homogeneous, long-lived population of American men of Japanese ancestry, well characterized for aging phenotypes. Genotyping was performed of single nucleotide polymorphisms, tagging most of the genetic variation across several genes in the insulin/IGF-1 signaling pathway or related gene networks that may be influenced by FOXO3, namely, ATF4, CBL, CDKN2, EXO1, and JUN. Two initial, marginal associations with longevity did not remain significant after correction for multiple comparisons, nor were they correlated with aging-related phenotypes.
- Subjects
SOMATOMEDIN C; MOLECULAR genetics; GENETICS of longevity; JAPANESE Americans; GENE regulatory networks; SINGLE nucleotide polymorphisms; GENETICS of aging; MULTIPLE comparisons (Statistics)
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2014, Vol 69A, Issue 3, p270
- ISSN
1079-5006
- Publication type
Article
- DOI
10.1093/gerona/glt082