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- Title
Additive Beneficial Effects of Lactotripeptides Intake With Regular Exercise on Endothelium-Dependent Dilatation in Postmenopausal Women.
- Authors
Yoshizawa, Mutsuko; Maeda, Seiji; Miyaki, Asako; Misono, Maiko; Choi, Youngju; Shimojo, Nobutake; Ajisaka, Ryuichi; Tanaka, Hirofumi
- Abstract
BackgroundPeripheral conduit artery endothelium-dependent dilatation decreases with aging in humans. Lactotripeptides (LTPs) and regular exercise can improve endothelium-dependent dilatation, but combining these lifestyle modifications may be more effective than either treatment alone. We conducted a randomized, place-controlled trial with four different intervention arms.MethodsA total of 43 postmenopausal women (50–65 years old) were randomly divided into placebo, LTP, exercise and placebo (Ex+placebo), or exercise and LTP (Ex+LTP) groups. LTP or placebo was administered orally for 8 weeks. The exercise groups completed an 8-week moderate aerobic exercise (walking or cycling) intervention.ResultsThere were no statistically significant differences in baseline flow-mediated dilatation (FMD) and most other key dependent variables among the groups. FMD significantly increased in the LTP, Ex+placebo, and Ex+LTP groups whereas no such changes were observed in the placebo control group. The magnitude of increases in FMD was significantly greater in the Ex+LTP group than other intervention groups.ConclusionWe concluded that LTP ingestion combined with regular aerobic exercise improves endothelium-dependent dilatation to a greater extent than monotherapy with either intervention alone in postmenopausal women.American Journal of Hypertension 2010; doi:10.1038/ajh.2009.270
- Subjects
HEART dilatation; POSTMENOPAUSE; ENDOTHELIUM; PLACEBOS; AEROBIC exercises; WOMEN
- Publication
American Journal of Hypertension, 2010, Vol 23, Issue 4, p368
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1038/ajh.2009.270