We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Alcohol Consumption and Augmentation Index in Healthy Young Men: The ARYA Study
- Authors
van Trijp, Marijke J.C.A.; Beulens, Joline W.J.; Bos, Willem J.W.; Uiterwaal, Cuno S.P.M.; Grobbee, Diederick E.; Hendriks, Henk F.J.; Bots, Michiel L.
- Abstract
Background: Light-to-moderate alcohol consumption is associated with a decreased risk of ischemic cardiovascular disease, whereas increased alcohol intake is related to hypertension and intracerebral hemorrhage. We studied the effect of alcohol consumption on the augmentation index (AIx), a measure of arterial wave reflection in a population of healthy young men. Methods: Three hundred twenty-nine men (mean age 28 years) from the Atherosclerosis Risk in Young Adults study (ARYA-study) were studied. The level of alcohol consumption and risk factors for cardiovascular disease were determined. The AIx was estimated by radial applanation tonometry using a Sphygmocor device. The relation between alcohol intake level and AIx was determined using linear regression models. Results: There was a positive graded relation between alcohol intake and AIx. Subjects who did not drink, who drank 1 to 2 glasses/d, or who drank ≥3 glasses of alcohol/d had, respectively, a −0.6% (95% confidence interval [CI] −4.2, 3.0), 0.2% (95% CI −2.6, 2.9), and 3.4% (95% CI 0.2, 6.7) difference in AIx compared with very light drinkers (<1 glass/d). After adjustment for current smoking, body mass index and HDL-cholesterol, those consuming >3 glasses/d had a 3.29% (95% confidence interval CI 0.01, 6.7) higher AIx compared with those consuming <1 glass/d. Conclusions: In a population of healthy young men, the heaviest drinkers had a significantly higher AIx. This finding supports the evidence that increased alcohol consumption is related to vascular damage at young age.
- Subjects
ALCOHOL drinking; YOUNG men; CARDIOVASCULAR diseases; ARTERIAL injuries; GLAUCOMA diagnosis
- Publication
American Journal of Hypertension, 2005, Vol 18, Issue 6, p792
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/j.amjhyper.2004.12.011