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- Title
B047: Aortic stiffness in never-treated hypertensives: lack of relation with myocardial hypertrophy and impaired left ventricular relaxation.
- Authors
Grandi*, A.M.; Imperiale, D.; Santillo, R.; Colombo, S.; Broggi, R.; Bertolini, A.; Guasti, L.; Selva, E.; Jessula, A.; Venco, A.
- Abstract
Aim of the study was the evaluation of the relationship between the degree of aortic stiffness and left ventricular (LV) morpho-functional changes in hypertension. Using carotid-femoral pulse wave velocity (PWV), as index of aortic distensibility, 24-hour blood pressure (BP) monitoring, Doppler and digitized M-mode echocardiography, we studied never-treated hypertensives (H) with aortic stiffness greater or similar to that expected (measured PWV > or ≤ PWV expected on the basis of age, sex, heart rate, BP, BMI). We enrolled never-treated H (day-time BP ≥ 140 and/or 90 mmHg): 49 H (Gr 1)(28 men, 42.7±10 years, BMI 25.6±3.7 Kg/m2) with PWV > expected PWV (11.6±2.2 vs 9.7±1.8 m/sec, p<0.0001), 41 H (Gr 2)(26 men, 45.6±10 years, BMI 25.6±3.5 Kg/m2) with PWV ≤ expected PWV (9.8±1.4 vs 10.5±1.6 m/sec, p=0.02). We evaluated: 24-h, day and night systolic and diastolic BP and heart rate (HR), % nocturnal BP fall, LV end-diastolic diameter (DD), relative wall thickness (RWT), LV mass index (LVMi), isovolumic relaxation time (IRT), peak E and A of transmitral flow velocity, E/A ratio, E wave deceleration time (Dec E), peak shortening (−dD/dt) and lengthening rate of LV diameter (+dD/dt), peak thinning rate of LV posterior wall (dW/dt).BP and HR values were similar between the 2 groups, as were LV DD, RWT, IRT and −dD/dt; 12 pts of Gr1 and 15 pts of Gr2 had LV hypertrophy (ns); 17 pts of Gr1 and 13 pts of Gr2 had impaired relaxation (ns). (See Table)PWV did not correlate with LV parameters in the 2 groups, neither considering the 90 pts together.In conclusion, in never-treated H, the degree of aortic stiffness is not related to the extent of LV morpho-functional changes: LVMi is even lower in H with higher PWV and the impairment of LV relaxation is similar between the 2 groups. It could only be observed that greater aortic stiffness is associated with a diastolic pattern (higher E wave amplitude and shorter E deceleration time) suggestive of reduced LV compliance.Am J Hypertens (2000) 13, 203A-204A; doi:S0895-7061(00)00708-1
- Publication
American Journal of Hypertension, 2000, Vol 13, p203A
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(00)00708-1