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- Title
Reduced bcl-2 concentrations in hypertensive patients after lisinopril or nifedipine administration.
- Authors
Buemi, Michele; Allegra, Alessandro; Corica, Francesco; Aloisi, Carmela; Ruello, Antonella; Giacobbe, Maria Stella; Di Pasquale, Giuseppe; Senatore, Massimino; Frisina, Nicola
- Abstract
In 30 patients with essential hypertension and 30 healthy control subjects, we evaluated blood concentrations of B cell leukemia-2 (bcl-2), a protooncogene that can reduce apoptosis. Bcl-2 concentrations were higher in hypertensive than in normotensive subjects. The increase in pressure due to a cold pressor test caused a further increase in blood bcl-2 concentrations, in both hypertensive and normotensive subjects. Treatment of hypertensive patients with hypotensive drugs caused a reduction in bcl-2 concentrations, which was more marked after administration of lisinopril than of nifedipine. The results suggest that concentrations of bcl-2 are increased in patients with hypertension, which could be an important factor in cell proliferation underlying posthypertensive vascular remodeling. Moreover, lisinopril and nifedipine appear to be capable of reducing bcl-2 concentrations, with potentially beneficial effects on vascular modifications in patients with hypertension.Am J Hypertens (1999) 12, 73-75; doi: S0895-7061(98)00217-9
- Publication
American Journal of Hypertension, 1999, Vol 12, Issue 1, p73
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(98)00217-9