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- Title
Variants of uncertain significance in precision oncology: nuance or nuisance?
- Authors
Mellgard, George S; Atabek, Zoey; LaRose, Meredith; Kastrinos, Fay; Bates, Susan E
- Abstract
The article offers a perspective on variants of unknown significance (VUS) in precision oncology and their impact on treatment choice. It presents clinical cases of patients with pancreatic cancer, a family history of cancer, and germline or somatic VUS, to illustrate the challenges of VUS in clinical practice. It considers pathogenic, germline mutations as loss-of-function mutations in tumor suppressors and presents data regarding pathogenic TET3 mutations and VUS.
- Subjects
TUMOR genetics; BIOPSY; ADENOCARCINOMA; PREDICTION models; GENOMICS; MICROBIAL virulence; GENETIC counseling; GENETIC variation; PANCREATIC tumors; GENES; ACCURACY; GENETIC mutation; DISEASE susceptibility; SEQUENCE analysis; GENETIC testing
- Publication
Oncologist, 2024, Vol 29, Issue 8, p641
- ISSN
1083-7159
- Publication type
Article
- DOI
10.1093/oncolo/oyae135