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- Title
Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1‐JAK2 positive myeloid sarcoma and acute B‐lymphoblastic leukemia.
- Authors
Rizzuto, Giuliana; Leoncin, Matteo; Imbergamo, Silvia; Taurino, Daniela; Mico, Maria Caterina; Tosi, Manuela; Michelato, Anna; Buklijas, Ksenija; Spinelli, Orietta; Lussana, Federico; Lessi, Federica; Pizzi, Marco; Bonaldi, Laura; Binotto, Gianni; Rambaldi, Alessandro; Gurrieri, Carmela
- Abstract
The translocation t(8;9)(p22;p24) results in the production of a chimeric PCM1‐JAK2 fusion protein leading to the constitutive activation of the Janus Kinase 2 that renders this disease potentially sensitive to ruxolitinib. Here, we report an interesting case of PCM1‐JAK2 myeloproliferative neoplasm evolving in myeloid sarcoma and B precursor ALL.
- Subjects
MYELOID sarcoma; ACUTE leukemia; RUXOLITINIB; MYELOPROLIFERATIVE neoplasms; CHIMERIC proteins
- Publication
Clinical Case Reports, 2022, Vol 10, Issue 1, p1
- ISSN
2050-0904
- Publication type
Case Study
- DOI
10.1002/ccr3.5212