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- Title
Fulminant onset of acute leukemia from normal hematopoiesis within 3 months of follow up for multiple myeloma treated with total therapy protocols.
- Authors
Singh, Zeba N.; Jethava, Yogesh; Post, Ginell R.; Alapat, Daisy; Sawyer, Jeffrey; Waheed, Sarah; Nair, Bijay; Usmani, Saad Z.; Bailey, Clyde; Petty, Nathan; Van Rhee, Frits; Barlogie, Bart
- Abstract
Key Clinical Message Assiduous surveillance for genetic aberrations is necessary in patients on cytotoxic therapies to detect therapy-related myeloid neoplasms (t- MN). Current modalities include metaphase cytogenetics and FISH. Since t- MN may develop abruptly in cytogenetically normal patients, a discussion exploring additional methods such as SNP-array and targeted-deep-sequencing to detect subchromosomal abnormalities is needed.
- Subjects
ACUTE leukemia; CYTOGENETICS; HEMATOPOIESIS; MULTIPLE myeloma treatment; LONGITUDINAL method; TUMORS; MEDICAL protocols; GENE therapy
- Publication
Clinical Case Reports, 2015, Vol 3, Issue 3, p183
- ISSN
2050-0904
- Publication type
Article
- DOI
10.1002/ccr3.180