We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Impact of Age on Long-Term Outcomes of Surgery for Malignant Pleural Mesothelioma.
- Authors
Yang, Chi-Fu Jeffrey; Yan, Brandon W; Meyerhoff, Robert Ryan; Saud, Shakir M; Gulack, Brian C; Speicher, Paul J; Hartwig, Matthew G; D'Amico, Thomas A; Harpole, David H; Berry, Mark F
- Abstract
<bold>Background: </bold>Although malignant pleural mesothelioma (MPM) is generally a disease associated with more advanced age, the association of age, treatment, and outcomes has not been well-characterized. We evaluated the impact of age on outcomes in patients with MPM to provide data for use in the treatment selection process for elderly patients with potentially resectable disease.<bold>Patients and Methods: </bold>Overall survival (OS) of patients younger than 70 and 70 years or older with Stage I to III MPM who underwent cancer-directed surgery or nonoperative management in the Surveillance, Epidemiology, and End Results database (2004-2010) was evaluated using multivariable Cox proportional hazard models and propensity score-matched analysis.<bold>Results: </bold>Cancer-directed surgery was used in 284 of 879 (32%) patients who met inclusion criteria, and was associated with improved OS in multivariable analysis (hazard ratio, 0.71; P = .001). Cancer-directed surgery was used much less commonly in patients 70 years and older compared with patients younger than 70 years (22% [109/497] vs. 46% [175/382]; P < .001), but patients 70 years and older had improved 1-year (59.4% vs. 37.9%) and 3-year (15.4% vs. 8.0%) OS compared with nonoperative management. The benefit of surgery in patients 70 years and older was observed even after propensity score-matched analysis was used to control for selection bias.<bold>Conclusion: </bold>Surgical treatment is associated with improved survival compared with nonoperative management for both patients younger than 70 years and patients aged 70 years or older.
- Subjects
TREATMENT of lung tumors; AGE distribution; REPORTING of diseases; LUNG tumors; MESOTHELIOMA; RESEARCH funding; SURVIVAL; TIME; TUMOR classification; PLEURAL tumors; PROPORTIONAL hazards models; TUMOR treatment; THERAPEUTICS
- Publication
Clinical Lung Cancer, 2016, Vol 17, Issue 5, p419
- ISSN
1525-7304
- Publication type
journal article
- DOI
10.1016/j.cllc.2016.03.002