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- Title
The role of hyperpolarization-activated cationic current in spike-time precision and intrinsic resonance in cortical neurons in vitro.
- Authors
Gastrein, Philippe; Campanac, Émilie; Gasselin, Célia; Cudmore, Robert H.; Bialowas, Andrzej; Carlier, Edmond; Fronzaroli-Molinieres, Laure; Ankri, Norbert; Debanne, Dominique
- Abstract
Non-technical summary We determined here the role of the hyperpolarization-activated cationic (h) current on the temporal organization of hippocampal activity in vitro. In CA1 pyramidal neurons the h-current has three main actions. In addition to setting intrinsic resonance frequency at ∼4 Hz, the h-current determines, through two main mechanisms, the temporal precision of action potentials evoked by excitatory postsynaptic potentials or following stimulation of inhibitory postsynaptic potentials (rebound spiking). We propose that h-channels participate in the fine tuning of oscillatory activity in hippocampal and neocortical networks.
- Subjects
CATIONS; TEMPORAL lobe; HIPPOCAMPUS (Brain); SYNAPSES; EVOKED potentials (Electrophysiology)
- Publication
Journal of Physiology, 2011, Vol 589, Issue 15, p3753
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/jphysiol.2011.209148