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- Title
Oligoartiküler Juvenil İdiopatik Artrit Hastalarının Aktif ve İnaktif Dönemdeki Sitokin Düzeylerinin Değerlendirilmesi.
- Authors
BAŞARAN, Özge; AYDIN, Fatma; ÇAKAR, Nilgün; UNCU, Nermin; BAL, Ajda; KIZILGÜN, Murat; ÇELİKEL ACAR, Banu
- Abstract
Objective: Juvenile idiopathic arthritis (JIA) is the most common rheumatologic disorder in childhood. It may cause short and long-term morbidities. Disease activity assessment in JIA patients is based on clinical examination and conventional parameters of inflammation. However, those parameters are not always in concordance and there could be difficulties in planning of therapy and management. The aim of this study is to evaluate the role of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor alfa (TNF-α) in determining disease activity of JIA patients. Material and Methods: Thirteen new diagnosed oligoarticular JIA patients and eight healthy controls were enrolled in the study. We investigated serum levels of IL-1β, TNF-α and IL-6 during both active and inactive phases of the disease. To evaluate the disease activity and quality of life we used JADAS-27 (Juvenile Arthritis Disease Activity Score) and JAQQ (Juvenile Arthritis Quality of Life Questionnaire). Results: There were no statistically significant differences regarding IL-6, IL-1β and TNF-α between the active phase, inactive phase and control group. Comparing JADAS-27 scores, there was a statistically significant decrease in inactive period compared with the active period (p=0.02). However, no significant difference was obtained about the JAQQ scores between active and inactive stages (p=0.382). Levels of IL-1β were significantly decreased in patients with low disease activity (JADAS-27 score ≤ 10) compared with those of severe and moderate disease activity (JADAS-27 score >10). On the other hand, no significant difference was obtained for IL-6 and TNF-α. Conclusion: There are few methods to evaluate the activation and remission periods of JİA. According to our results and the literature assessment of cytokine levels has limited value in diagnosis, monitoring and evaluating the severity of the oligoarticular JIA patients.
- Publication
Journal of Pediatric Disease / Türkiye Çocuk Hastalıkları Dergisi, 2019, Vol 13, Issue 4, p252
- ISSN
1307-4490
- Publication type
Article
- DOI
10.12956/tchd.546933