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- Title
Methylchloroisothiazolinone and methylisothiazolinone contact allergy: an occupational perspective.
- Authors
Urwin, Rachel; Warburton, Katharine; Carder, Melanie; Turner, Susan; Agius, Raymond; Wilkinson, S Mark
- Abstract
Background Sensitivity to either methylchloroisothiazolinone ( MCI)/methylisothiazolinone ( MI) or MI has increased, with a reported frequency of up to 11.1% among dermatitis patients, the main context being allergic contact dermatitis caused by MCI or MCI/ MI in personal care products. Case reports have described occupational allergic contact dermatitis caused by MI in paints and within the beauty industry. Patients/materials/methods This study identified incident cases of occupational allergic contact dermatitis caused by MCI/ MI and or MI reported from 1996 to 2012 to a UK-wide surveillance scheme ( EPIDERM), with the aim of identifying changes in incidence over the study period. Results The data show an increase in occupational allergic contact dermatitis caused by MCI/ MI and or MI from 1996 to 2012 of 4.1% [95% confidence interval ( CI) 1.6-6.9] per annum. Analysis by industry showed a 3.8% (95% CI: −0.3 to 8.0) per annum increase in those exposed to personal care products in the workplace as a primary exposure [healthcare workers, 8.1% (95% CI: 2.1-14.4) per annum; beauty workers, 6.6% (95% CI: −2.2 to 16.2) per annum; hairdressers, 1.5% (95% CI: −4.7 to 8.1) per annum]. There was a 6.3% (95% CI: 1.8-10.9) per annum increase for manufacturing workers. A statistically significant rise in the frequency of occupational allergic contact dermatitis was shown to be attributable to MCI/ MI and or MI between 1996 and 2012. Conclusion The findings support recommendations for a review of the regulations relating to MCI/ MI and/or MI in cosmetic and personal care products and in industrial settings.
- Subjects
HETEROCYCLIC compounds; BIOCIDES; CONTACT dermatitis; SKIN inflammation; HYGIENE products; OCCUPATIONAL diseases
- Publication
Contact Dermatitis (01051873), 2015, Vol 72, Issue 6, p381
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1111/cod.12379