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- Title
Is the Recurrence of Helicobacter pylori Infection After Eradication Therapy Resultant from Recrudescence or Reinfection, in Japan.
- Authors
Okimoto, Tadayoshi; Murakami, Kazunari; Sato, Ryugo; Miyajima, Hajime; Nasu, Masaru; Kagawa, Jiro; Kodama, Masaaki; Fujioka, Toshio
- Abstract
ABSTRACT Background. Reinfection of Helicobacter pylori after eradication is rare in developed countries but most often occurs within 1 year. In the present study, we attempted to differentiate between reinfection and recrudescence of H. pylori strains between 6 months and 6 years after successful eradication in Japan, a country with a high prevalence of H. pylori infection. Materials and Methods. After successful eradication of H. pylori , 274 patients were followed up by endoscopy and urea breath test. In recurrent patients, H. pylori strains isolated initially and after recurrence were compared using PCR-based restriction fragment length polymorphism (RFLP) analysis. Results. Recurrence of H. pylori occurred in 15 of 274 patients (5.5%) at 6 months after eradication and the annual recurrence rate was 2.0% per patient year (between 1 and 6 years). PCR-based RFLP analysis of H. pylori strains isolated initially and after recurrence showed that 62.5% (at 6 months) and 100% (after 1 years) of bacteria were of different strains. Conclusion. Reinfection of H. pylori was not as rare at 6 months after eradication as reported previously, and up to 6 years after eradication, the annual reinfection rate is 2.0% per patient year in Japan.
- Subjects
JAPAN; HELICOBACTER pylori infections; DISEASE relapse; POLYMERASE chain reaction
- Publication
Helicobacter, 2003, Vol 8, Issue 3, p186
- ISSN
1083-4389
- Publication type
Article
- DOI
10.1046/j.1523-5378.2003.00143.x