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- Title
Roles for BLyS family members in meeting the distinct homeostatic demands of innate and adaptive B cells.
- Authors
Sindhava, Vishal J.; Scholz, Jean L.; Cancro, Michael P.; Morel, Laurence; Davidson, Anne
- Abstract
B-1 and B-2 B cell populations have different progenitors, receptor diversity, anatomic location, and functions - suggesting vastly differing requisites for homeostatic regulation. There is evidence that the B lymphocyte stimulator (BLyS) family of cytokines and receptors, key factors in the homeostatic regulation of B-2 B cell subsets, is also a major player in the B-1 compartment. Here we review the development and differentiation of these two primary B cell lineages and their immune functions. We discuss evidence that BLyS or a proliferation-inducing ligand (APRIL) availability in different anatomic sites, coupled with signature BLyS receptor expression patterns on different B cell subsets, may be important for homeostatic regulation of B-1 as well as B-2 populations. Finally, we extend our working model of B cell homeostasis to integrate B-1s.
- Subjects
B cells; IMMUNOREGULATION; CELL proliferation; ANTIGEN presenting cells; CYTOKINES
- Publication
Frontiers in Immunology, 2013, Vol 4, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2013.00037