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- Title
A clinical study of Japanese patients with ulcer induced by low-dose aspirin and other non-steroidal anti-inflammatory drugs.
- Authors
Nakashima, S.; Arai, S.; Mizuno, Y.; Yoshino, K.; Ando, S.; Nakamura, Y.; Sugawara, K.; Koike, M.; Saito, E.; Naito, M.; Nakao, M.; Ito, H.; Hamaoka, K.; Rai, F.; Asakura, Y.; Akamatu, M.; Fujimori, K.; Inao, M.; Imai, Y.; Ota, S.
- Abstract
: The incidence and severity of non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastro-duodenal ulcer have not been extensively studied in Japan.: We performed a prospective study to clarify NSAIDs-induced gastro-duodenal injury, focusing especially on low-dose aspirin (L-A).: Two hundred and thirty-eight patients with bleeding peptic ulcers admitted to our hospital. History of taking NSAIDs and anti-ulcer drugs was obtained from all patients who underwent endoscopic examinations. The lesion scores of patients taking L-A were classified numerically from zero (no lesion) to five (ulcer).: The NSAIDs were associated with 28.2% of hemorrhagic ulcers. The rates of patients using L-A, loxoprofen, diclofenac, and combination of two of these drugs were 27, 16, 10 and 9%, respectively. Co-administered anti-ulcer drugs were cytoprotective anti-ulcer drugs (27%), H2 receptor antagonists (16%), PPI (4%), and none (53%). In patients taking L-A, H2 receptor antagonists were used most frequently. TheHPwas positive in 63% of L-A-induced ulcer cases and in 69% of NSAIDs other than low-dose aspirin-induced ulcer cases. The lesion scores of patients taking L-A with H2 receptor antagonists or PPI were significantly lower than those of patients who were taking only L-A (P < 0.05).: Approximately one-third of hospitalized patients with NSAIDs-induced hemorrhagic ulcer showed an association with L-A. Prospective randomized controlled trials including H2 receptor antagonists are required to establish preventive efforts aimed at L-A-induced gastro-duodenal injury.
- Subjects
ULCERS; ASPIRIN; ANTI-inflammatory agents; NONSTEROIDAL anti-inflammatory agents; HOSPITAL patients; PEPTIC ulcer
- Publication
Alimentary Pharmacology & Therapeutics, 2005, Vol 21, p60
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2005.02476.x