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- Title
A controlled trial of ondansetron in the pruritus of cholestasis.
- Authors
O'Donohue, J. W.; Pereira, S. P.; Ashdown, A. C.; Haigh, C. G.; Wilkinson, J. R.; Williams, R.
- Abstract
: In patients with pruritus of cholestasis, response to conventional drug treatment may be unsatisfactory. Activation of 5-hydroxytryptamine receptors on dermal sensory nerve-endings plays a role in the perception of pruritus. The 5-hydroxytryptamine3 receptor antagonist, ondansetron, has been used in the treatment of pruritus of cholestasis, but there are few controlled data.: To determine whether ondansetron is effective in treating the pruritus of cholestasis.: A total of 19 patients with resistant pruritus were randomized, double blind, to receive either ondansetron 8 mg or placebo as a single intravenous bolus, followed by oral ondansetron 8 mg or placebo twice daily for 5 days. Patients’ perception of pruritus was recorded hourly using a visual analogue scale, and scratching activity measured by means of a piezo-electric crystal attached to the fingernail.: Mean pruritus score using visual analogue scale and scratching activity were reduced on the first treatment day compared with baseline in both the ondansetron and placebo groups (P < 0.05), but there were no significant differences in mean pruritus perception or scratching activity between the two groups.: Ondansetron was of no benefit in this group of pruritic patients during short-term treatment.
- Subjects
CHOLESTASIS; ITCHING; OBSTRUCTIVE jaundice; SEROTONIN; BILIOUS diseases &; biliousness; JAUNDICE
- Publication
Alimentary Pharmacology & Therapeutics, 2005, Vol 21, Issue 8, p1041
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2005.02430.x