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- Title
Regulation of Zishen Qinggan (Shuangyi) Prescription to Insulin Resistance of GK Rats.
- Authors
Chunyu TIAN; Chen XING; Haimei BO; Liang ZHU; Xiaojin LA; Huijuan CAO; Xin YAN; Yuyang YANG; Xuemei ZHOU; Ji'an LI; Yongsen JIA
- Abstract
[Objective] To study the effects of Zishen Qinggan (Shuangyi) Prescription on blood glucose, HbAlc (glycosylated hemoglobin Alc), C-peptide (C-P), glucagon-like peptide (GLP-1), and α-glucosidase activity in GK (Goto-Kakizaki) rats. [Methods] Selected fasting blood glucose (FBG) >11.1mmol/L GK rats and randomly divided into groups: model group, Zishen Qinggan (Shuangyi) Prescription low dosage (ig, 400 mg/kg/d), medium dosage (ig, 800 mg/kg/d), and high dosage groups (ig, 1600 mg/kg/d), and metformin group (ig, 85 mg/kg/d). After continuous administration for 28 d, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), HbA1c, C-P, GLP-1 and α-glucosidase actvity were detected. [Results] Compared with the control group, FBG and HbA1c of the model group was significanty higher (P < 0.01); compared with the model group, Zishen Qinggan (Shuangyi) Prescription could significantly reduce the levels of blood glucose, HbA1c, and the elevated blood glucose levels after 120 min of glucose loading in OGTT (P <0.05, P<0.01), and also can significanty improve the level of C-P, GLP-1 (P <0.05, P <0. 01), reduce Homa-IR, and inhibit α-glucosidase activity. [Conclusions] Zishen Qinggan (Shuangyi) Prescription can effectively reduce the blood glucose of GK rats, the action mechanism of which is possibly that it can improve insulin resistance, increase GLP-1 content and inhibit α-glucosidase activiiy.
- Subjects
PLANT cells &; tissues; MEDICINAL plants; INSULIN antibodies; IMMUNOGLOBULINS; PEPTIDE hormones
- Publication
Medicinal Plant, 2017, Vol 8, Issue 3, p19
- ISSN
2152-3924
- Publication type
Article