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- Title
Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2.
- Authors
O'Donovan, M. C.; Norton, N.; Williams, H.; Peirce, T.; Moskvina, V.; Nikolov, I.; Hamshere, M.; Carroll, L.; Georgieva, L.; Dwyer, S.; Holmans, P.; Marchini, J. L.; Spencer, C. C. A.; Howie, B.; Leung, H.-T.; Giegling, I.; Hartmann, A. M.; Möller, H.-J.; Morris, D. W.; Shi, Y.
- Abstract
We and others have previously reported linkage to schizophrenia on chromosome 10q25–q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 single-nucleotide polymorphisms (SNPs) mapping to 10q25–q26 that had been typed in a genome-wide association study (GWAS) of schizophrenia (479 UK cases/2937 controls). SNPs with P<0.01 (n=40) were genotyped in an additional 163 UK cases and those markers that remained nominally significant at P<0.01 (n=22) were genotyped in replication samples from Ireland, Germany and Bulgaria consisting of a total of 1664 cases with schizophrenia and 3541 controls. Only one SNP, rs17101921, was nominally significant after meta-analyses across the replication samples and this was genotyped in an additional six samples from the United States/Australia, Germany, China, Japan, Israel and Sweden (n=5142 cases/6561 controls). Across all replication samples, the allele at rs17101921 that was associated in the GWAS showed evidence for association independent of the original data (OR 1.17 (95% CI 1.06–1.29), P=0.0009). The SNP maps 85 kb from the nearest gene encoding fibroblast growth factor receptor 2 (FGFR2) making this a potential susceptibility gene for schizophrenia.Molecular Psychiatry (2009) 14, 30–36; doi:10.1038/mp.2008.108; published online 23 September 2008
- Subjects
SCHIZOPHRENIA; PSYCHOSES; GENETIC polymorphisms; PATHOLOGICAL psychology; MENTAL health
- Publication
Molecular Psychiatry, 2009, Vol 14, Issue 1, p30
- ISSN
1359-4184
- Publication type
Article
- DOI
10.1038/mp.2008.108