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- Title
The Effects of COVID-19 on the Placenta During Pregnancy.
- Authors
Rad, Habib Sadeghi; Röhl, Joan; Stylianou, Nataly; Allenby, Mark C.; Bazaz, Sajad Razavi; Warkiani, Majid E.; Guimaraes, Fernando S. F.; Clifton, Vicki L.; Kulasinghe, Arutha
- Abstract
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. The virus primarily affects the lungs where it induces respiratory distress syndrome ranging from mild to acute, however, there is a growing body of evidence supporting its negative effects on other system organs that also carry the ACE2 receptor, such as the placenta. The majority of newborns delivered from SARS-CoV-2 positive mothers test negative following delivery, suggesting that there are protective mechanisms within the placenta. There appears to be a higher incidence of pregnancy-related complications in SARS-CoV-2 positive mothers, such as miscarriage, restricted fetal growth, or still-birth. In this review, we discuss the pathobiology of COVID-19 maternal infection and the potential adverse effects associated with viral infection, and the possibility of transplacental transmission.
- Subjects
COVID-19; PREGNANCY complications; VIRUS diseases; SARS-CoV-2; PLACENTA
- Publication
Frontiers in Immunology, 2021, Vol 12, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2021.743022