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- Title
Tumor cell‐intrinsic RIG‐I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice.
- Authors
Poeck, Hendrik; Wintges, Alexander; Dahl, Sarah; Bassermann, Florian; Haas, Tobias; Heidegger, Simon
- Abstract
Tumor cell-intrinsic RIG-I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice We found that tumor-intrinsic RIG-I signaling induces caspase-3-mediated programmed tumor cell death, cross-presentation of tumor-associated antigen by DCs, and finally activation of tumor-specific CD8 SP + sp T cells. As described in Ref. [2], anti-CTLA-4 delayed tumor growth, but was significantly less potent in mice bearing RIG-I SP -/- sp tumors, resulting in faster tumor growth and shortened survival compared to WT tumors (Fig 1B and C).
- Subjects
MELANOMA; IPILIMUMAB; CANCER treatment; SMALL nuclear RNA; TYPE I interferons; PATTERN perception receptors
- Publication
European Journal of Immunology, 2021, Vol 51, Issue 6, p1531
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.202049158