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- Title
Loss of DNAM-1 contributes to CD8.
- Authors
Cella, Marina; Presti, Rachel; Vermi, William; Lavender, Kerry; Turnbull, Emma; Ochsenbauer-Jambor, Christina; Kappes, John C.; Ferrari, Guido; Kessels, Lisa; Williams, Ian; McMichael, Andrew J.; Haynes, Barton F.; Borrow, Persephone; Colonna, Marco
- Abstract
The hallmark of chronic viral infections is a progressive exhaustion of antigen-specific CD8 T cells that leads to persisting viral replication. It is generally believed that exhaustion is a consequence of the accumulation of multiple inhibitory receptors on CD8 T cells that makes them dysfunctional. Here, we show that during human chronic HIV-1 infection, a CD8 T-cell positive costimulatory pathway mediated by DNAX-activating molecule-1 is also disrupted. Thus, DNAX-activating molecule-1 downregulation on CD8 T cells aggravates the impairment of CTL effector function in chronic HIV-1 infection.
- Publication
European Journal of Immunology, 2010, Vol 40, Issue 4, p949
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200940234