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- Title
Antigen presentation and transfer between B cells and macrophages.
- Authors
Harvey, Bohdan P.; Gee, Renelle J.; Haberman, Ann M.; Shlomchik, Mark J.; Mamula, Mark J.
- Abstract
B cells play an active role in directing immunity against specific proteins in part because of their capacity to sequester antigen via B cell receptor (BCR). Our prior findings indicate that B cells can initiate an immune response in vivo to self proteins independent of other antigen-presenting cells (APC). However, these studies also demonstrated that both dendritic cells and macrophages are important in the ongoing immune response. The present work illustrates a mechanism by which antigen acquired by B cells through BCR is specifically transferred to other APC, in particular, macrophages. The transfer of antigen is dependent on the specificity of BCR and requires direct contact between the cells, but does not require MHC compatibility between the cells and is independent of the activation state of macrophages. Antigen transfer is functional, in that macrophages, which received B cell derived-antigen, can activate CD4 T cells. Overall, these results define a novel mechanism by which B cells can focus immunity toward a specific antigen and transfer the ability to activate CD4 T cells to other APC.
- Publication
European Journal of Immunology, 2007, Vol 37, Issue 7, p1739
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200636452